Abstract
We have isolated a complementary DNA clone containing sequences homologous to those encoding the alpha-subunit of a mouse muscle nicotinic acetylcholine receptor. Based on the structural similarities between the encoded protein and the muscle acetylcholine receptor alpha-subunit, and the presence of hybridizing RNA species in the brain, we propose that this clone codes for a neural nicotinic acetylcholine receptor alpha-subunit.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / physiology
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Cell Line
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Cloning, Molecular
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DNA / genetics
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Genes
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Macromolecular Substances
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Mice
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Nucleic Acid Hybridization
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Pheochromocytoma
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RNA, Messenger / genetics
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Rats
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Receptors, Nicotinic / genetics*
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Sequence Homology, Nucleic Acid
Substances
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Macromolecular Substances
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RNA, Messenger
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Receptors, Nicotinic
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DNA