AI-based prediction models demonstrate equal or surpassing performance compared to experienced physicians in various research settings. However, only a few have made it into clinical practice. Further, there is no standardized protocol for integrating AI-based physician support systems into the daily clinical routine to improve healthcare delivery. Generally, AI/physician collaboration strategies have not been extensively investigated. A recent study compared four potential strategies for AI model deployment and physician collaboration to investigate the performance of an AI model trained to identify signs of acute respiratory distress syndrome (ARDS) on chest X-ray images. Here we discuss strategies and challenges with AI/physician collaboration when AI-based decision support systems are implemented in the clinical routine.