Biological function and research progress of N6-methyladenosine binding protein heterogeneous nuclear ribonucleoprotein A2B1 in human cancers

Yue Wu; An Li; Can Chen; Zhang Fang; Lujun Chen; Xiao Zheng

doi:10.3389/fonc.2023.1229168

Biological function and research progress of N⁶-methyladenosine binding protein heterogeneous nuclear ribonucleoprotein A2B1 in human cancers

Front Oncol. 2023 Jul 20:13:1229168. doi: 10.3389/fonc.2023.1229168. eCollection 2023.

Authors

Yue Wu^{1

2

3}, An Li^{1

2

3}, Can Chen^{1

2

3}, Zhang Fang^{1

2

3}, Lujun Chen^{1

2

3}, Xiao Zheng^{1

2

3}

Affiliations

¹ Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
² Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
³ Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China.

Abstract

N⁶-methyladenosine (m⁶A) is the most prevalent internal modification found in both mRNA and lncRNA. It exerts reversible regulation over RNA function and affects RNA processing and metabolism in various diseases, especially tumors. The m⁶A binding protein, hnRNPA2B1, is extensively studied as a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) protein family. It is frequently dysregulated and holds significant importance in multiple types of tumors. By recognizing m⁶A sites for variable splicing, maintaining RNA stability, and regulating translation and transport, hnRNPA2B1 plays a vital role in various aspects of tumor development, metabolism, and regulation of the immune microenvironment. In this review, we summarized the latest research on the functional roles and underlying molecular mechanisms of hnRNPA2B1. Moreover, we discussed its potential as a target for tumor therapy.

Keywords: biological mechanisms; cancer therapy; epigenetics; hnRNPA2B1; m6A; tumor.

Publication types

Review

Grants and funding

This work was supported by National Natural Science Foundation of China (82172689, 81902386); China Postdoctoral Science Foundation (2021M700543, 2021M700547).