A sweet way to regulate cellular growth: OGT and mTOR join forces

Pedro Latorre-Muro; Pere Puigserver

doi:10.1016/j.molcel.2023.07.016

A sweet way to regulate cellular growth: OGT and mTOR join forces

Mol Cell. 2023 Aug 17;83(16):2832-2833. doi: 10.1016/j.molcel.2023.07.016.

Authors

Pedro Latorre-Muro¹, Pere Puigserver²

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 37595551
DOI: 10.1016/j.molcel.2023.07.016

Abstract

In this issue, Xu and Pan et al¹ report a glucose-sensing and activation mechanism of mTORC1 through the glycosyltransferase OGT, which activates Raptor, allowing lysosomal targeting of mTORC1 to promote cell proliferation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle
Cell Proliferation
Glycosyltransferases*
Mechanistic Target of Rapamycin Complex 1 / genetics
TOR Serine-Threonine Kinases* / genetics

Substances

TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
Glycosyltransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding