Midline cutaneous anomalies of the craniospinal axis

Faliang Ren; Lindsey Bressler; Laura Pruitt; Hua Wang; Li Liu; Dirk M Elston

doi:10.1016/j.jaad.2023.06.062

Midline cutaneous anomalies of the craniospinal axis

J Am Acad Dermatol. 2023 Dec;89(6):1238-1244. doi: 10.1016/j.jaad.2023.06.062. Epub 2023 Aug 19.

Authors

Faliang Ren¹, Lindsey Bressler², Laura Pruitt², Hua Wang³, Li Liu³, Dirk M Elston²

Affiliations

¹ Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: [email protected].
² Department of Dermatology & Dermatological Surgery, Medical University of South Carolina, Charleston, South Carolina.
³ Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, China.

PMID: 37598328
DOI: 10.1016/j.jaad.2023.06.062

Abstract

Patients with midline cutaneous anomalies of the craniospinal axis can be indicative of underlying embryonic defects, such as neural tube defects. Lack of familiarity with these midline aberrant skin findings may lead to misdiagnosis and delayed treatment. In this review, midline cutaneous anomalies of the craniospinal axis including aplasia cutis congenita, cranial and spinal dysraphism, and other developmental anomalies are explored in detail with emphasis on cutaneous clues to the diagnosis and appropriate workup.

Keywords: aplasia cutis congenita; cranial dysraphism; craniospinal axis; cutaneous neural heterotopias; dermoid cyst; midline cutaneous anomalies; nasal glial heterotopia; pediatric dermatology; spinal dysraphism.

Publication types

Review

MeSH terms

Humans
Skin
Spinal Dysraphism* / diagnosis