Dopamine receptor divergence revealed using a common ligand

Trends Pharmacol Sci. 2023 Oct;44(10):637-639. doi: 10.1016/j.tips.2023.08.002. Epub 2023 Aug 19.

Abstract

Rational drug design for G protein-coupled receptors (GPCRs) remains a challenging area. A new study from the Xu, Roth, and Zhang groups provides a complete set of active structures for the entire dopamine receptor family bound with rotigotine that will aid in designing selective agonists for these important therapeutic targets.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Drug Design*
  • Humans
  • Ligands
  • Receptors, Dopamine*

Substances

  • Receptors, Dopamine
  • Ligands