Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial

Am J Respir Crit Care Med. 2023 Nov 1;208(9):995-997. doi: 10.1164/rccm.202306-1102LE.

Authors

Sarah Svenningsen^{1

2

3}, Melanie Kjarsgaard^{1

3}, Ehsan Haider^{2

4}, Carmen Venegas^{1

3}, Norman Konyer², Yonni Friedlander^{1

2}, Neha Nasir⁵, Colm Boylan^{2

4}, Miranda Kirby⁵, Parameswaran Nair^{1

3}

Affiliations

¹ Firestone Institute for Respiratory Health and.
² Imaging Research Center, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
³ Department of Medicine and.
⁴ Department of Radiology, McMaster University, Hamilton, Ontario, Canada; and.
⁵ Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.

PMID: 37603097
DOI: 10.1164/rccm.202306-1102LE

No abstract available

Publication types

Randomized Controlled Trial
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal, Humanized* / therapeutic use
Asthma* / drug therapy
Double-Blind Method
Humans
Injections, Subcutaneous
Mucus
Severity of Illness Index
Treatment Outcome

Substances

Antibodies, Monoclonal, Humanized
dupilumab

Associated data

ClinicalTrials.gov/NCT03884842