Recurrent RARG trinary fusion and ligand binding domain truncation in variant acute promyelocytic leukemia resistant to retinoic acid but sensitive to homoharringtonine-based therapy

Int J Lab Hematol. 2023 Dec;45(6):1016-1019. doi: 10.1111/ijlh.14150. Epub 2023 Aug 22.
No abstract available

Publication types

  • Letter

MeSH terms

  • Homoharringtonine
  • Humans
  • Leukemia, Promyelocytic, Acute* / drug therapy
  • Leukemia, Promyelocytic, Acute* / genetics
  • Ligands
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Protein Domains
  • Retinoic Acid Receptor alpha
  • Tretinoin / therapeutic use

Substances

  • Tretinoin
  • Homoharringtonine
  • Ligands
  • Oncogene Proteins, Fusion
  • Retinoic Acid Receptor alpha