Late-onset neurodegenerative manifestations in patients with cirrhosis: acquired hepatocerebral degeneration - a neglected diagnosis

Ceylon Med J. 2022 Mar 31;67(1):22-25. doi: 10.4038/cmj.v67i1.9557.

Abstract

Acquired hepatocerebral degeneration (AHCD) is an acquired, extrapyramidal, neurodegenerative condition, encountered in patients with cirrhosis. It is an uncommon and usually irreversible condition, resulting in widespread cerebral, basal ganglia and cerebellar damage. We describe here four cases of AHCD, with varying presentations, highlighting the need for increased awareness of this condition, to avoid diagnostics delays and unnecessary management.

Keywords: Extra-pyramidal, neurodegeneration, movement disorder, cirrhosis, portal hypertension.

MeSH terms

  • Hepatolenticular Degeneration* / complications
  • Hepatolenticular Degeneration* / diagnosis
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / diagnosis