Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study

Qiaolin Wang; Sujie Jia; Qianjin Lu; Ming Zhao

doi:10.1080/08916934.2023.2250103

Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study

Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.

Authors

Qiaolin Wang^{1

2}, Sujie Jia³, Qianjin Lu^{1

2}, Ming Zhao^{1

2}

Affiliations

¹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
² Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China.
³ Department of Pharmacy, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

PMID: 37621181
DOI: 10.1080/08916934.2023.2250103

Abstract

As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.

Keywords: Mendelian randomization; Systemic lupus erythematosus; celiac disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
Celiac Disease* / complications
Celiac Disease* / epidemiology
Celiac Disease* / genetics
Humans
Lupus Erythematosus, Systemic* / complications
Lupus Erythematosus, Systemic* / epidemiology
Lupus Erythematosus, Systemic* / genetics