Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study

Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.

Abstract

As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.

Keywords: Mendelian randomization; Systemic lupus erythematosus; celiac disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoimmune Diseases*
  • Celiac Disease* / complications
  • Celiac Disease* / epidemiology
  • Celiac Disease* / genetics
  • Humans
  • Lupus Erythematosus, Systemic* / complications
  • Lupus Erythematosus, Systemic* / epidemiology
  • Lupus Erythematosus, Systemic* / genetics