Comparative Study of ZnO-and-TiO2-Nanoparticles-Functionalized Polyvinyl Alcohol/Chitosan Bionanocomposites for Multifunctional Biomedical Applications

Annu; Zafar Iqbal Bhat; Khalid Imtiyaz; M Moshahid A Rizvi; Saiqa Ikram; Dong Kil Shin

doi:10.3390/polym15163477

Comparative Study of ZnO-and-TiO₂-Nanoparticles-Functionalized Polyvinyl Alcohol/Chitosan Bionanocomposites for Multifunctional Biomedical Applications

Polymers (Basel). 2023 Aug 19;15(16):3477. doi: 10.3390/polym15163477.

Authors

Annu^{1

2}, Zafar Iqbal Bhat³, Khalid Imtiyaz³, M Moshahid A Rizvi³, Saiqa Ikram¹, Dong Kil Shin²

Affiliations

¹ Thin-Film Engineering and Materials Laboratory, School of Mechanical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
² Bio/Polymers Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
³ Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.

Abstract

This study aimed to synthesize chitosan/polyvinyl alcohol (CS/PVA)-based zinc oxide (ZnO) and titanium dioxide (TiO₂) hybrid bionanocomposites (BNCs) and observe their comparative accomplishment against the skin cancer cell line, A431, and antioxidant potential. CS was blended with PVA to form polymeric films reinforced with the immobilization of ZnO and TiO₂ nanoparticles (NPs), separately. The optimization of the BNCs was done via physicochemical studies, viz. moisture content, swelling ratio, and contact angle measurements. The free radical scavenging activity was observed for 1,1-diphenyl-2-picryl-hydrazyl, and the antibacterial assay against the Escherichia coli strain showed a higher zone of inhibition. Furthermore, the anticancer activity of the synthesized BNCs was revealed against the skin cancer cell line A431 under varying concentrations of 50, 100, 150, 200, and 300 μg/mL. The anticancer study revealed a high percent of cancerous cell inhibition (70%) in ZnO BNCs as compared to (61%) TiO₂ BNCs in a dose-dependent manner.

Keywords: antioxidant; biomedical; bionanocomposites; chitosan; polyvinyl alcohol; skin cancer A431; titanium dioxide NPs; zinc oxide NPs.

Grants and funding

This research was supported by the Technology Innovation Program (#20010170) funded by the Ministry of Trade, Industry & Energy (MOTIE), and the 2023 Yeungnam University Research Grant, Republic of Korea.