Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent

Eleanor Roberts; Elke M van Veen; Helen Byers; Ofra Barnett-Griness; Naomi Gronich; Flavio Lejbkowicz; Mila Pinchev; Miriam J Smith; Anthony Howell; William G Newman; Emma R Woodward; Elaine F Harkness; Adam R Brentnall; Jack Cuzick; Gad Rennert; Sacha J Howell; D Gareth Evans

doi:10.1016/j.gim.2023.100963

Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent

Genet Med. 2023 Oct;25(10):100963. doi: 10.1016/j.gim.2023.100963. Epub 2023 Aug 30.

Authors

Eleanor Roberts¹, Elke M van Veen², Helen Byers², Ofra Barnett-Griness³, Naomi Gronich⁴, Flavio Lejbkowicz³, Mila Pinchev³, Miriam J Smith², Anthony Howell⁵, William G Newman², Emma R Woodward², Elaine F Harkness⁶, Adam R Brentnall⁷, Jack Cuzick⁷, Gad Rennert⁴, Sacha J Howell⁵, D Gareth Evans⁸

Affiliations

¹ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
² Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
³ Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
⁴ Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
⁵ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Nightingale/Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Manchester Breast Centre, Manchester Cancer Research Centre, The Christie Hospital, Manchester, United Kingdom.
⁶ Nightingale/Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
⁷ Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Population Health, Charterhouse, Square, London, United Kingdom.
⁸ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Nightingale/Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Manchester Breast Centre, Manchester Cancer Research Centre, The Christie Hospital, Manchester, United Kingdom.

PMID: 37650883
DOI: 10.1016/j.gim.2023.100963

No abstract available

Publication types

Published Erratum