Combined Gadolinium and Boron Neutron Capture Therapies for Eradication of Head-and-Neck Tumor Using Gd10B6 Nanoparticles under MRI/CT Image Guidance

Munusamy Shanmugam; Naresh Kuthala; Xiangyi Kong; Chi-Shiun Chiang; Kuo Chu Hwang

doi:10.1021/jacsau.3c00250

Combined Gadolinium and Boron Neutron Capture Therapies for Eradication of Head-and-Neck Tumor Using Gd¹⁰B₆ Nanoparticles under MRI/CT Image Guidance

JACS Au. 2023 Aug 4;3(8):2192-2205. doi: 10.1021/jacsau.3c00250. eCollection 2023 Aug 28.

Authors

Munusamy Shanmugam¹, Naresh Kuthala¹, Xiangyi Kong², Chi-Shiun Chiang³, Kuo Chu Hwang¹

Affiliations

¹ Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan ROC.
² Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
³ Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan R.O.C.

Abstract

Eradication of head-and-neck (H&N) tumors is very difficult and challenging because of the characteristic feature of frequent recurrence and the difficulty in killing cancer stem cells. Neutron capture therapy (NCT) is emerging as a noninvasive potential modality for treatments of various types of tumors. Herein, we report that 98.5% ¹⁰B-enriched anti-EGFR-Gd¹⁰B₆ nanoparticles can not only deliver large doses of 158 μg ¹⁰B/g tumor tissues as well as 56.8 μg ¹⁵⁷Gd/g tumor tissues with a very high tumor-to-blood (T/B) ¹⁰B ratio of 4.18, but also exert very effective CT/MRI image-guided combined GdBNCT effects on killing cancer stem cells and eradication of recurrent head-and-neck (H&N) tumors. This leads to a long average half-lifespan of 81 days for H&N tumor-bearing mice, which is a record-making result, and surpasses the best result reported in the literature using combined radiotherapy and T cell-mediated immunotherapy (70 d).