[Inter-laboratory Study on the Modified Methods for Analyzing Bisphenol A Content for Migration Tests from Polycarbonate Food Apparatuses, Containers, and Packaging]

Yohei Kataoka; Motoh Mutsug; Tomoyuki Abe; Yutaka Abe; Atsuko Ushiyama; Yosuke Uchiyama; Hiroyuki Ohno; Kimiyasu Ohashi; Takamitsu Kazama; Arisa Kimura; Yasushi Kobayashi; Midori Kondo; Tamaki Sato; Shunsuke Zama; Yoshiyuki Takahashi; Arisa Takezawa; Aoi Tanaka; Yoshimitsu Terui; Shinichiro Nagai; Chie Nomura; Kotaro Hanazawa; Masato Hayakawa; Naoyuki Hirabayashi; Tomoharu Fujiyoshi; Saki Hotta; Hiroyuki Miyakawa; Yuko Murayama; Michiyo Yotsuyanagi; Kazunari Watanabe; Kyoko Sato

doi:10.3358/shokueishi.64.154

[Inter-laboratory Study on the Modified Methods for Analyzing Bisphenol A Content for Migration Tests from Polycarbonate Food Apparatuses, Containers, and Packaging]

Shokuhin Eiseigaku Zasshi. 2023;64(4):154-160. doi: 10.3358/shokueishi.64.154.

[Article in Japanese]

Authors

Yohei Kataoka¹, Motoh Mutsug¹, Tomoyuki Abe², Yutaka Abe¹, Atsuko Ushiyama³, Yosuke Uchiyama⁴, Hiroyuki Ohno⁵, Kimiyasu Ohashi⁶, Takamitsu Kazama⁷, Arisa Kimura⁸, Yasushi Kobayashi⁹, Midori Kondo¹, Tamaki Sato¹⁰, Shunsuke Zama¹¹, Yoshiyuki Takahashi¹², Arisa Takezawa¹³, Aoi Tanaka¹⁴, Yoshimitsu Terui¹⁵, Shinichiro Nagai¹⁶, Chie Nomura¹⁷, Kotaro Hanazawa¹⁸, Masato Hayakawa¹⁹, Naoyuki Hirabayashi²⁰, Tomoharu Fujiyoshi²¹, Saki Hotta²², Hiroyuki Miyakawa²³, Yuko Murayama²⁴, Michiyo Yotsuyanagi¹, Kazunari Watanabe²⁵, Kyoko Sato¹

Affiliations

¹ National Institute of Health Sciences.
² Japan Food Hygiene Association.
³ Kawasaki City Institute for Public Health.
⁴ Kanagawa Prefectural Institute of Public Health.
⁵ Nagoya City Public Health Research Institute.
⁶ Japan Recreation and Miscellaneous Goods Safety Laboratory.
⁷ Tama Laboratory, Japan Food Research Laboratories.
⁸ Shizuoka City Institute of Environmental Sciences and Public Health.
⁹ Saitama Prefectural Institute of Public Health.
¹⁰ Fukuoka Institute of Health and Environmental Sciences.
¹¹ Saito Laboratory, Japan Food Research Laboratories.
¹² Research Center of Chiba Pharmaceutical Association.
¹³ Nagano Environmental Conservation Research Institute.
¹⁴ Nippon Kaiji Kentei Kyokai.
¹⁵ Japan Food Inspection Corporation.
¹⁶ Tokyo Kenbikyo-in: Toyomi-Center BLDG.
¹⁷ Osaka Institute of Public Health.
¹⁸ Japan Inspection Association of Food and Food Industry Environment.
¹⁹ High Polymer Test & Evaluation Center, Osaka office, Japan Chemical Innovation and Inspection Institute.
²⁰ Food and Drug Safety Center.
²¹ Food Analysis Technology Center SUNATEC.
²² Aichi Prefectural Institute of Public Health.
²³ Tokyo Metropolitan Institute of Public Health.
²⁴ Saitama City Institute of Health Science and Research.
²⁵ High Polymer Test & Evaluation Center, Tokyo office, Japan Chemical Innovation and Inspection Institute.

PMID: 37673605
DOI: 10.3358/shokueishi.64.154

Abstract

An inter-laboratory study involving 24 laboratories was conducted to validate the modified analytical method for the migration solution of heptane for the determination of bisphenol A migrating from polycarbonate food processing materials. In this study, two concentrations of samples were blindly coded. Each laboratory determined the analyte (bisphenol A, phenol and p-tert-butylphenol) concentration in each sample according to the established protocol. The obtained values were analyzed statistically using internationally accepted guidelines. Horwitz ratios were calculated based on the reproducibility relative standard deviation (RSD_R), which was estimated from the inter-laboratory study, and predicted RSD_R, which was calculated using the Horwitz/Thompson equation. Horwitz ratios of the two samples ranged from 0.15 to 0.37 for the three compounds, meeting the performance criteria of less than 2 set by the Codex Alimentarius for analytical method approval. These results showed that this modified analytical method shows good performance as an analytical method for the migration solution of heptane.

Keywords: A bisphenol A; inter-laboratory study; polycarbonate.

Publication types

English Abstract

MeSH terms

Heptanes*
Phenols*
Reproducibility of Results

Substances

bisphenol A
polycarbonate
Phenols
Heptanes