Locus of control: How the brain gives up when failure is taken for granted

Joseph M Villarin; Christoph Kellendonk

doi:10.1016/j.neuron.2023.08.013

Locus of control: How the brain gives up when failure is taken for granted

Neuron. 2023 Sep 6;111(17):2620-2622. doi: 10.1016/j.neuron.2023.08.013.

Authors

Joseph M Villarin¹, Christoph Kellendonk²

Affiliations

¹ Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: [email protected].
² Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Molecular Pharmacology & Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: [email protected].

Abstract

After repeatedly failing to get out of a stressful, uncontrollable environment, mice switch from escape behavior to inactivity. In this issue of Neuron, Li et al. identify a circuit involving noradrenergic projections from the locus coeruleus to GABAergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior.

Publication types

Comment

MeSH terms

Adaptation, Psychological
Animals
Brain*
Ethnicity
GABAergic Neurons
Humans
Locus Coeruleus*
Mice

Grants and funding

T32 MH018870/MH/NIMH NIH HHS/United States