Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block

Jingmin Zhong; Qingjie Wang; Yilin Xie; Zhaorong Niu; Diwei Zhou

doi:10.1111/cyt.13296

Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block

Cytopathology. 2024 Jan;35(1):149-152. doi: 10.1111/cyt.13296. Epub 2023 Sep 9.

Authors

Jingmin Zhong¹, Qingjie Wang¹, Yilin Xie¹, Zhaorong Niu¹, Diwei Zhou¹

Affiliation

¹ Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 37688410
DOI: 10.1111/cyt.13296

Abstract

Mesenchymal chondrosarcoma (MC) is a rare but extremely aggressive type of chondrosarcoma distinguished by the presence of both primitive mesenchymal cells and fully developed chondroid tissue. The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1::NCOA2 fusion using next-generation sequencing, serve as vital indicators for an accurate diagnosis.

Publication types

Case Reports

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Bone Neoplasms*
Cell Cycle Proteins
Chondrosarcoma, Mesenchymal* / diagnosis
Chondrosarcoma, Mesenchymal* / genetics
Chondrosarcoma, Mesenchymal* / metabolism
High-Throughput Nucleotide Sequencing
Humans
Immunohistochemistry
Nuclear Receptor Coactivator 2 / metabolism
Pleural Effusion*

Substances

Basic Helix-Loop-Helix Transcription Factors
Cell Cycle Proteins
NCOA2 protein, human
Nuclear Receptor Coactivator 2
HEY1 protein, human