Development and validation of a nomogram (APGRC) to predict the presence of germline DNA damage repair pathogenic variants in Asian patients with prostate cancer

Tingwei Zhang; Yu Wei; Boon Hao Hong; Takayuki Sumiyoshi; Enya Hui Wen Ong; Hao Zeng; Yonghong Li; Chi-Fai Ng; Jian Pan; Bangwei Fang; Beihe Wang; Junlong Wu; Hongkai Wang; Shusuke Akamatsu; Melvin Lee Kiang Chua; Dingwei Ye; Yao Zhu

doi:10.1002/ctm2.1411

Development and validation of a nomogram (APGRC) to predict the presence of germline DNA damage repair pathogenic variants in Asian patients with prostate cancer

Clin Transl Med. 2023 Sep;13(9):e1411. doi: 10.1002/ctm2.1411.

Authors

Tingwei Zhang^{1

2

3}, Yu Wei^{1

2

3}, Boon Hao Hong⁴, Takayuki Sumiyoshi⁵, Enya Hui Wen Ong⁴, Hao Zeng⁶, Yonghong Li⁷, Chi-Fai Ng⁸, Jian Pan^{1

2

3}, Bangwei Fang^{1

2

3}, Beihe Wang^{1

2

3}, Junlong Wu^{1

2

3}, Hongkai Wang^{1

2

3}, Shusuke Akamatsu^{5

9}, Melvin Lee Kiang Chua^{4

10

11}, Dingwei Ye^{1

2

3}, Yao Zhu^{1

2

3}

Affiliations

¹ Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
³ Shanghai Genitourinary Cancer Institute, Shanghai, China.
⁴ Division of Medical Sciences, National Cancer Centre Singapore, Singapore.
⁵ Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁶ Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
⁷ Department of Urology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
⁸ Department of Surgery, and SH Ho Urology Center, Chinese University of Hong Kong, Hong Kong, Hong Kong.
⁹ Department of Urology, Nagoya University Graduate School of Medicine, Aichi, Japan.
¹⁰ Department of Head and Neck and Thoracic Cancers, Division of Radiation Oncology, National Cancer Centre Singapore, Singapore.
¹¹ Oncology Academic Programme, Duke-NUS Medical School, Singapore.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Damage / genetics
Germ Cells
Humans
Male
Nomograms*
Prostatic Neoplasms* / diagnosis
Prostatic Neoplasms* / genetics