In order to evaluate the existence of a correlation between the hemorheological and the psychobehavioral pattern in chronic cerebrovascular disorder (CCVD) patients, 54 elderly CCVD patients were enrolled in the study. After a thorough clinical and instrumental examination they underwent a hemorheological and psychobehavioral assessment. The results showed a clear correlation between the severity of the psychobehavioral disorder and the hemorheological alterations, particularly with regard to the cellular factors. A hypothesis to explain these findings and future research trends are also discussed.