Case report metastatic SMARCB1 (INI1)-deficient gastric undifferentiated carcinoma in pleural effusion: A case report and literature review

Jingmin Zhong; Yilin Xie; Zhaorong Niu; Mingfei Xie; Diwei Zhou

doi:10.1111/cyt.13307

Case report metastatic SMARCB1 (INI1)-deficient gastric undifferentiated carcinoma in pleural effusion: A case report and literature review

Cytopathology. 2024 Jan;35(1):153-156. doi: 10.1111/cyt.13307. Epub 2023 Sep 14.

Authors

Jingmin Zhong¹, Yilin Xie¹, Zhaorong Niu¹, Mingfei Xie², Diwei Zhou¹

Affiliations

¹ Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Radiology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 37706577
DOI: 10.1111/cyt.13307

Abstract

INI1-deficient gastric undifferentiated carcinoma is a rare tumour that may present as high-grade epithelioid morphology without apparent rhabdoid tumour cells. Syncytial tumour cells may be a crucial clue in such cases, especially in cytological specimens. Cell block and immunocytochemical staining can be valuable tools in achieving an accurate diagnosis.

Keywords: INI-1; SMARCB1; gastric undifferentiated carcinoma; pleural effusion.

Publication types

Review
Case Reports

MeSH terms

Biomarkers, Tumor
Carcinoma* / diagnosis
Carcinoma* / pathology
Diagnosis, Differential
Humans
Pleural Effusion* / diagnosis
Rhabdoid Tumor* / diagnosis
Rhabdoid Tumor* / pathology
SMARCB1 Protein / genetics
Stomach Neoplasms* / diagnosis

Substances

Biomarkers, Tumor
SMARCB1 protein, human
SMARCB1 Protein