Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies

Peder Ez Larson; Jenna Ml Bernard; James A Bankson; Nikolaj Bøgh; Robert A Bok; Albert P Chen; Charles H Cunningham; Jeremy Gordon; Jan-Bernd Hövener; Christoffer Laustsen; Dirk Mayer; Mary A McLean; Franz Schilling; James Slater; Jean-Luc Vanderheyden; Cornelius von Morze; Daniel B Vigneron; Duan Xu; HP 13C MRI Consensus Group

Current Methods for Hyperpolarized [1-¹³C]pyruvate MRI Human Studies

ArXiv [Preprint]. 2023 Nov 22:arXiv:2309.04040v2.

Authors

Peder Ez Larson^{1

2}, Jenna Ml Bernard¹, James A Bankson³, Nikolaj Bøgh⁴, Robert A Bok¹, Albert P Chen⁵, Charles H Cunningham^{6

7}, Jeremy Gordon¹, Jan-Bernd Hövener⁸, Christoffer Laustsen⁴, Dirk Mayer^{9

10}, Mary A McLean^{11

12}, Franz Schilling¹³, James Slater¹, Jean-Luc Vanderheyden^{5

14}, Cornelius von Morze¹⁵, Daniel B Vigneron^{1

2}, Duan Xu^{1

2}; HP 13C MRI Consensus Group

Affiliations

¹ Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA.
² UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA 94143, USA.
³ Department of Imaging Physics, MD Anderson Medical Center, Houston, TX, USA.
⁴ The MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
⁵ GE Healthcare, Menlo Park, California, USA.
⁶ Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.
⁷ Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
⁸ Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Am Botanischen Garten 14, 24118, Kiel, Germany.
⁹ Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
¹⁰ Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
¹¹ Department of Radiology, University of Cambridge, Cambridge, United Kingdom.
¹² Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Center, Cambridge, United Kingdom.
¹³ Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
¹⁴ JLVMI Consulting LLC, Dousman, WI, USA.
¹⁵ Department of Radiology, Washington University, St. Louis, MO, USA.

PMID: 37731660
PMCID: PMC10508833

Abstract

MRI with hyperpolarized (HP) ¹³C agents, also known as HP ¹³C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of hyperpolarized agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-¹³C]pyruvate - by far the most commonly used agent, which sits at a key metabolic junction in glycolysis. The paper is divided into four major topic areas: (1) HP ¹³C-pyruvate preparation, (2) MRI system setup and calibrations, (3) data acquisition and image reconstruction, and (4) data analysis and quantification. In each area, we identified the key components for a successful study, summarized both published studies and current practices, and discuss evidence gaps, strengths, and limitations. This paper is the output of the "HP ¹³C MRI Consensus Group" as well as the ISMRM Hyperpolarized Media MR and Hyperpolarized Methods & Equipment study groups. It further aims to provide a comprehensive reference for future consensus building as the field continues to advance human studies with this metabolic imaging modality.

Keywords: Hyperpolarized MRI; carbon-13; dissolution dynamic nuclear polarization; metabolic imaging; pyruvate.

Publication types

Preprint

Grants and funding

P41 EB013598/EB/NIBIB NIH HHS/United States