Chemotaxis: Dendritic cells as trendsetters of the immune response

Amy L Shergold; Ryan M Devlin; Alex L Young; Ed W Roberts

doi:10.1016/j.cub.2023.08.009

Chemotaxis: Dendritic cells as trendsetters of the immune response

Curr Biol. 2023 Sep 25;33(18):R957-R959. doi: 10.1016/j.cub.2023.08.009.

Authors

Amy L Shergold¹, Ryan M Devlin¹, Alex L Young¹, Ed W Roberts²

Affiliations

¹ CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK.
² CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, UK; School of Cancer Studies, University of Glasgow, Glasgow, UK. Electronic address: [email protected].

PMID: 37751709
DOI: 10.1016/j.cub.2023.08.009

Abstract

A new study reports that dendritic cells actively shape the CCL19 chemokine gradient to which they respond and that the chemokine receptor CCR7 both senses CCL19 and mediates its internalisation. Generation of local changes in chemokines allows coordination of movement over longer distances than previous models could explain.

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MeSH terms

Chemotaxis*
Defense Mechanisms*
Dendritic Cells
Immunity
Movement