Systemic and Ophthalmic Manifestations of Chikungunya Fever

Ocul Immunol Inflamm. 2024 Oct;32(8):1796-1803. doi: 10.1080/09273948.2023.2260464. Epub 2023 Sep 29.

Abstract

Purpose: Chikungunya is a re-emerging viral infection across the globe. The purpose of this article is to review the systemic and ophthalmic manifestations associated with chikungunya fever.

Method: A review of literature was conducted using online databases.

Results: In this report, we have reviewed the presently available literature on uveitis caused by chikungunya and highlighted the current knowledge of its clinical manifestations, imaging features, laboratory diagnostics, and the available therapeutic modalities from the systemic and ophthalmic standpoint.

Conclusions: Ocular involvement in chikungunya infection may occur at the time of systemic manifestations or it may occur as a delayed presentation many weeks after the fever. Treatment relies on a supportive therapy for systemic illness. Treatment of ocular manifestation depends on the type of manifestations and usually includes a combination of topical and oral steroids.

Keywords: Chikungunya; epidemic retinitis; ocular manifestations; systemic manifestations; viral retinitis; viral uveitis.

Publication types

  • Review

MeSH terms

  • Chikungunya Fever* / complications
  • Chikungunya Fever* / diagnosis
  • Chikungunya virus*
  • Eye Infections, Viral* / diagnosis
  • Eye Infections, Viral* / drug therapy
  • Eye Infections, Viral* / etiology
  • Eye Infections, Viral* / virology
  • Humans
  • Uveitis / diagnosis
  • Uveitis / drug therapy
  • Uveitis / etiology
  • Uveitis / virology