Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance

Affiliations

• ¹ Department of Chemical Engineering, University of Texas, Austin, TX, USA.
• ² Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Lank Genitourinary Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• ³ Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ⁴ Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
• ⁵ Department of Chemical Engineering, University of Texas, Austin, TX, USA; Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
• ⁶ Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
• ⁷ Lank Genitourinary Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• ⁸ Worcester Polytechnic Institute, Worcester, MA, USA.
• ⁹ Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• ¹⁰ Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, USA.
• ¹¹ Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• ¹² Children's Medical Center Research Institute, University of Texas Southwestern, Dallas, TX, USA.
• ¹³ Department of Chemical Engineering, University of Texas, Austin, TX, USA; Department of Molecular Biosciences, University of Texas, Austin, TX, USA; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA; Department of Oncology, University of Texas Dell Medical School, LiveSTRONG Cancer Institutes, Austin, TX, USA.
• ¹⁴ Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: [email protected].
• ¹⁵ Department of Molecular Biosciences, University of Texas, Austin, TX, USA; Department of Oncology, University of Texas Dell Medical School, LiveSTRONG Cancer Institutes, Austin, TX, USA. Electronic address: [email protected].