[Transverse myelitis and cauda equina syndrome followed by varicella in a patient with varicella-zoster virus infection]

Rinsho Shinkeigaku. 2023 Oct 25;63(10):637-642. doi: 10.5692/clinicalneurol.cn-001833. Epub 2023 Sep 30.
[Article in Japanese]

Abstract

A 74-year-old man was admitted to our hospital with complaints of weakness in the lower extremities, urinary retention for 10 days, and generalized vesicular rash for 7 days. Spinal magnetic resonance imaging showed contrast enhancement at the Th12-L1 level of the spinal cord and cauda equina. Serum and cerebrospinal fluid varicella-zoster virus (VZV)-immunoglobulin (Ig) G antibody titers were markedly elevated, and VZV-IgM was detected in cerebrospinal fluid. The patient was diagnosed with VZV transverse myelitis and cauda equina syndrome with subsequent varicella and was treated with acyclovir and prednisolone. Two months later, muscle weakness, and dysuria had almost completely resolved. We hypothesize that latent VZV in the ganglia reactivated and caused transverse myelitis, which subsequently spread to the body via the bloodstream, resulting in the development of varicella.

Keywords: cauda equina syndrome; recurrence; transverse myelitis; varicella; varicella-zoster virus.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Cauda Equina Syndrome* / complications
  • Chickenpox* / complications
  • Herpes Zoster* / complications
  • Herpesvirus 3, Human
  • Humans
  • Immunoglobulin G
  • Male
  • Myelitis* / diagnosis
  • Myelitis* / drug therapy
  • Myelitis* / etiology
  • Myelitis, Transverse*

Substances

  • Immunoglobulin G