Fatal ampicillin-sulbactam anaphylaxis in a 34-year-old male

Marielle C Young; Chantal Lemoine; John J O Accarino; Sandra B Nelson; Jerome C Crowley; Kimberly G Blumenthal

doi:10.1016/j.jacig.2023.100136

Fatal ampicillin-sulbactam anaphylaxis in a 34-year-old male

J Allergy Clin Immunol Glob. 2023 Jul 4;2(4):100136. doi: 10.1016/j.jacig.2023.100136. eCollection 2023 Nov.

Authors

Marielle C Young¹, Chantal Lemoine¹, John J O Accarino¹, Sandra B Nelson^{2

3}, Jerome C Crowley^{4

3}, Kimberly G Blumenthal^{1

3}

Affiliations

¹ Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass.
² Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Mass.
³ Harvard Medical School, Boston, Mass.
⁴ Division of Anesthesia and Pain Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Mass.

Abstract

A 34-year-old man receiving his first dose of ampicillin-sulbactam for osteomyelitis in a hospital setting experienced fatal drug-induced anaphylaxis.

Keywords: Drug anaphylaxis; aminopenicillin; anaphylaxis; penicillin allergy; skin test.

Publication types

Case Reports