BH3 mimetics in relapsed and refractory adult acute lymphoblastic leukemia: a Campus ALL real-life study

Francesco Malfona; Ilaria Tanasi; Matteo Piccini; Cristina Papayannidis; Vincenzo Federico; Valentina Mancini; Elisa Roncoroni; Elisabetta Todisco; Simona Bianchi; Giulia Ciotti; Patrizia Chiusolo; Massimo Gentile; Valentina Gianfelici; Fabio Giglio; Michele Malagola; Antonino Mulé; Francesco Saraceni; Calogero Vetro; Francesco Zallio; Luca Vincenzo Cappelli; Giovanni Pizzolo; Robin Foà; Massimiliano Bonifacio; Sabina Chiaretti

doi:10.3324/haematol.2023.283684

BH3 mimetics in relapsed and refractory adult acute lymphoblastic leukemia: a Campus ALL real-life study

Haematologica. 2024 Mar 1;109(3):988-993. doi: 10.3324/haematol.2023.283684.

Authors

Francesco Malfona¹, Ilaria Tanasi², Matteo Piccini³, Cristina Papayannidis⁴, Vincenzo Federico⁵, Valentina Mancini⁶, Elisa Roncoroni⁷, Elisabetta Todisco⁸, Simona Bianchi¹, Giulia Ciotti⁹, Patrizia Chiusolo¹⁰, Massimo Gentile¹¹, Valentina Gianfelici¹², Fabio Giglio¹³, Michele Malagola¹⁴, Antonino Mulé¹⁵, Francesco Saraceni¹⁶, Calogero Vetro¹⁷, Francesco Zallio¹⁸, Luca Vincenzo Cappelli¹, Giovanni Pizzolo², Robin Foà¹, Massimiliano Bonifacio², Sabina Chiaretti¹⁹

Affiliations

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University.
² Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona.
³ SOD Ematologia, Università Di Firenze, AOU Careggi, Firenze.
⁴ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna.
⁵ Hematology and Transplant Unit, Vito Fazzi Hospital, Lecce.
⁶ ASST Grande Ospedale Metropolitano Niguarda, Milano.
⁷ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia.
⁸ IEO, European Institute of Oncology IRCCS, Milan.
⁹ Onco Hematology, Department of Oncology-Veneto Institute of Oncology IOV-IRCCS, Padua.
¹⁰ Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore.
¹¹ Hematology Unit AO of Cosenza, Cosenza, Italy; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende.
¹² Department Hematology-Oncology- Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro.
¹³ Haematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan.
¹⁴ Blood Diseases and Cell Therapies Unit, Bone Marrow Transplant Unit, "ASST-Spedali Civili" Hospital of Brescia, Department of Clinical and Experimental Sciences, University of Brescia, Brescia.
¹⁵ Division of Onco-Hematology, AO Ospedali Riuniti Villa Sofia-Cervello, Palermo.
¹⁶ Hematology and Stem Cell Transplant, Ancona University Hospital.
¹⁷ Hematology and BMT Unit, Azienda Ospedaliero Universitaria Policlinico "G.Rodolico-San Marco", Catania.
¹⁸ Hematology Department, SS Antonio and Biagio and C. Arrigo Hospital, Alessandria.
¹⁹ Hematology, Department of Translational and Precision Medicine, Sapienza University. [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy

Grants and funding

Funding: This work was supported by Abbvie, by supplying venetoclax and navitoclax in accordance with Ministerial Decree 09/07/2017. The authors thank the Associazione Italiana per la Ricerca sul Cancro (AIRC) 5x1000, Special Program Metastases (21198), Milan (Italy), for supporting RF; Progetti di Rilevante Interesse Nazionale (PRIN) Italia, 2017PPS2X4 project, for supporting SC; and Finanziamento Medi Progetti Universitari 2021, for supporting SC (Sapienza University of Rome).