Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

Am J Hematol. 2023 Dec;98(12):E383-E386. doi: 10.1002/ajh.27109. Epub 2023 Oct 6.

Authors

Aline Hatem^{1

2}, Sofia Esperti³, Nicoletta Murciano^{4

5}, Min Qiao^{5

6}, Maria Giustina Rotordam⁴, Nadine Becker⁴, Elie Nader³, Felix Maurer⁶, Laurent Pérès^{1

2}, Guillaume Bouyer^{1

2}, Lars Kaestner^{5

6}, Philippe Connes³, Stéphane Egée^{1

2}

Affiliations

¹ Sorbonne Université, CNRS, UMR8227 LBI2M, Station Biologique de Roscoff, Roscoff, France.
² Laboratory of Excellence GR-Ex, Paris, France.
³ Laboratory LIBM EA7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France.
⁴ Research and Development, Nanion Technologies, Munich, Germany.
⁵ Theoretical Medicine and Biosciences, Saarland University, Homburg, Germany.
⁶ Experimental Physics, Saarland University, Saarbrücken, Germany.

PMID: 37800361
DOI: 10.1002/ajh.27109

Abstract

THC triggers a pronounced entry of Ca²⁺ , which may be deleterious, into sickle cell red blood cells via activation of the TRPV2 channel.

© 2023 Wiley Periodicals LLC.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell* / drug therapy
Dronabinol* / adverse effects
Erythrocytes
Humans

Substances

Dronabinol