The healing process after skin injury is a dynamic process of interaction between various cells, cytokines, and extracellular matrix. Fibrosis is one of the main ways of skin injury repair. The process of fibrosis involves the regulation of many factors. Studies have shown that nerve regeneration-related protein (NREP) plays a key role in the fibrosis of skin tissue and organs. Based on the mechanism of skin fibrosis, this paper discusses the construction of tertiary structure of NREP, summarizes the effects of NREP and different cells in the skin on skin fibrosis and the research progress of mechanism of NREP in skin fibrosis, thus providing new ideas for the treatment of skin fibrosis diseases.
皮肤损伤后的愈合是多种细胞、细胞因子及细胞外基质相互作用的动态过程，纤维化是皮肤损伤修复的主要方式之一。纤维化过程涉及多种因素调节，研究显示神经再生相关蛋白（NREP）在皮肤组织和脏器的纤维化中起关键作用。该文从皮肤纤维化的机制出发，探讨NREP三级结构的构建，归纳NREP与皮肤中不同细胞对皮肤纤维化的影响、NREP在皮肤纤维化中的作用机制研究进展，以为皮肤纤维化疾病的治疗提供新的思路。.