Digging into phenotype change in mismatch repair deficient endometrial carcinoma and treatment with immune checkpoint inhibition, a case report

Macarena Rey-Cárdenas; Lucia Parrilla-Rubio; Luis Manso; Rodrigo Sanchez-Bayona; Carmen Alvarez-Conejo; Ainhoa Madariaga

doi:10.1016/j.gore.2023.101278

Digging into phenotype change in mismatch repair deficient endometrial carcinoma and treatment with immune checkpoint inhibition, a case report

Gynecol Oncol Rep. 2023 Sep 25:49:101278. doi: 10.1016/j.gore.2023.101278. eCollection 2023 Oct.

Authors

Macarena Rey-Cárdenas¹, Lucia Parrilla-Rubio², Luis Manso¹, Rodrigo Sanchez-Bayona¹, Carmen Alvarez-Conejo³, Ainhoa Madariaga¹

Affiliations

¹ Medical Oncology Department, 12 de Octubre University Hospital, Madrid, Spain.
² Pathology Department, 12 de Octubre University Hospital, Madrid, Spain.
³ Gynecology Department, 12 de Octubre University Hospital, Madrid, Spain.

Abstract

•False negative cases for mismatch repair determination by immunohistochemistry may occur.•The mismatch repair phenotype in endometrial carcinoma impacts on therapeutic decision making.•Retesting for mismatch repair at relapse of endometrial carcinoma should be considered.

Keywords: Deficient MMR; Endometrial carcinoma; Immunotherapy; Microsatellite instability; RESPONSE biomarker.

Publication types

Case Reports