Molecular docking analysis of imiquimod with the TGF-β targets for oral carcinoma

TGF-βsignalling pathway is the main signalling pathways that regulate various biological functions such as cell proliferation, apoptosis, metabolic dysregulation, and metastasis in many cancer cells. Previous studies have elaborated the role of TGF-βsignalling targets have a significant regulatory function in various cancers. Moreover targeting the epithelial to mesenchymal transition markers in oral squamous cell carcinoma not yet elucidated. Therefore, it is of interest to document the molecular docking analysis of TGF-βsignalling pathway targets such as Smad2, GATA2 and MAFG with imiquimod. These results suggest that targeting the TGF-βsignaling pathway downstream targets with imiquimod might leads to an improved outcome as potential therapeutic options in oral carcinoma.