Streptococcus pyogenes emm 98.1 variants activate inflammatory caspases in human neutrophils

Virulence. 2023 Dec;14(1):2264090. doi: 10.1080/21505594.2023.2264090. Epub 2023 Oct 13.

Authors

Jonathan G Williams^{1

2}, Ronald Sluyter¹, Martina L Sanderson-Smith¹

Affiliations

¹ Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.
² NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.

Abstract

CovRS, control of virulence regulatory system; GAS, Group A Streptococcus; PMN, polymorphonuclear leukocyte.

Keywords: Neutrophils; Streptococcus pyogenes; caspases; cell death; inflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics
Caspases / genetics
Humans
Neutrophils*
Streptococcal Infections*
Streptococcus pyogenes / genetics
Virulence

Substances

Caspases
Bacterial Proteins

Grants and funding

The work was supported by the Illawarra Health and Medical Research Institute [2018 NHMRC Near Miss Scheme].