Interactions between nanoparticle corona proteins and the immune system

Trieu Tm Tran; Steve R Roffler

doi:10.1016/j.copbio.2023.103010

Interactions between nanoparticle corona proteins and the immune system

Curr Opin Biotechnol. 2023 Dec:84:103010. doi: 10.1016/j.copbio.2023.103010. Epub 2023 Oct 17.

Authors

Trieu Tm Tran¹, Steve R Roffler²

Affiliations

¹ Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
² Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address: [email protected].

PMID: 37852029
DOI: 10.1016/j.copbio.2023.103010

Abstract

The corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. Notably, it highlights the latest findings on the generation of antibody responses to the polyethylene glycol (PEG) component of SARS-CoV-2 mRNA vaccines and possible mechanisms of hypersensitivity reactions induced by antibodies that bind to NPs. Finally, we briefly outline how the NP interactions with immune cells can be harnessed to enhance targeted delivery of nanocargos to disease sites.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Immune System
Nanomedicine
Nanoparticles*
Proteins*
Tissue Distribution

Substances

Proteins