Transthyretin Cardiac Amyloidosis Disguised as Light Chain Amyloidosis or Multiple Myeloma?

Andrew P Stein; Eldon L Matthia; Stephen A Petty; Brian Stewart; Juan R Vilaro; Mohammad A Z Al-Ani; Mustafa M Ahmed; Juan M Aranda Jr; John W Hiemenz; Alex M Parker

doi:10.1016/j.amjcard.2023.10.031

Transthyretin Cardiac Amyloidosis Disguised as Light Chain Amyloidosis or Multiple Myeloma?

Am J Cardiol. 2024 Jan 1:210:85-92. doi: 10.1016/j.amjcard.2023.10.031. Epub 2023 Oct 16.

Affiliations

¹ Department of Medicine, University of Florida, Gainesville, Florida. Electronic address: [email protected].
² Department of Medicine, University of Florida, Gainesville, Florida; Department of Cardiovascular Medicine, University of Florida, Gainesville, Florida.
³ Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida.
⁴ Department of Medicine, University of Florida, Gainesville, Florida; Department of Hematology/Oncology Medicine, University of Florida, Gainesville, Florida.

PMID: 37852567
DOI: 10.1016/j.amjcard.2023.10.031

Abstract

We describe 2 challenging cases of cardiac transthyretin amyloidosis initially treated as cardiac amyloidosis light chain in the setting of active myeloma. Endomyocardial biopsy with mass spectrometry was essential to confirm the appropriate diagnosis to direct the treatment.

Keywords: cardiac amyloidosis; endomyocardial biopsy; genetic testing; mass spectrometry.

Published by Elsevier Inc.

Publication types

Case Reports

MeSH terms

Amyloid Neuropathies, Familial* / complications
Amyloid Neuropathies, Familial* / diagnosis
Cardiomyopathies* / diagnosis
Heart
Humans
Multiple Myeloma* / complications
Multiple Myeloma* / diagnosis
Prealbumin

Substances

Prealbumin