In this study, we present two cases of Klebsiella pneumoniae, one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.
Keywords: KPC mutated; Klebsiella pneumoniae; blaKPC-33; blaNDM-1; cefiderocol; cefiderocol resistance; ceftazidime/avibactam; ceftazidime/avibactam resistance; co-resistance; virulence factors.