High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases
J Clin Invest
.
2023 Dec 15;133(24):e169619.
doi: 10.1172/JCI169619.
Authors
Alisa A Mueller
1
,
Takanori Sasaki
1
,
Joshua W Keegan
2
,
Jennifer P Nguyen
2
,
Alec Griffith
2
,
Alice M Horisberger
1
,
Thomas Licata
1
,
Elizabeth Fieg
1
,
Ye Cao
1
,
Mehreen Elahee
1
,
Kathryne E Marks
1
,
Daimon P Simmons
1
3
,
Lauren C Briere
4
,
Laurel A Cobban
1
,
J Carl Pallais
1
,
Frances A High
5
,
Melissa A Walker
6
,
Jenny J Linnoila
6
,
Jeffrey A Sparks
1
,
V Michael Holers
7
,
Karen H Costenbader
1
;
Undiagnosed Diseases Network
;
David A Sweetser
4
5
,
Joel B Krier
1
,
Joseph Loscalzo
1
,
James A Lederer
2
,
Deepak A Rao
1
Affiliations
1
Department of Medicine.
2
Department of Surgery, and.
3
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
4
Center for Genomic Medicine.
5
Department of Pediatrics, and.
6
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
7
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
PMID:
37874643
PMCID:
PMC10721141
DOI:
10.1172/JCI169619
No abstract available
Keywords:
Autoimmune diseases; Autoimmunity; Inflammation; Rheumatology.
Publication types
Research Support, N.I.H., Extramural
MeSH terms
Autoimmune Diseases* / diagnosis
Autoimmunity
Humans
Immunophenotyping
Grants and funding
K08 NS101084/NS/NINDS NIH HHS/United States
P30 AR072577/AR/NIAMS NIH HHS/United States
P30 AR070253/AR/NIAMS NIH HHS/United States
R01 AR080659/AR/NIAMS NIH HHS/United States
T32 AR007530/AR/NIAMS NIH HHS/United States
K08 AR072791/AR/NIAMS NIH HHS/United States
U01 HG007943/HG/NHGRI NIH HHS/United States
UL1 TR001102/TR/NCATS NIH HHS/United States
U01 HG007530/HG/NHGRI NIH HHS/United States
U01 HG007690/HG/NHGRI NIH HHS/United States
R01 AR077607/AR/NIAMS NIH HHS/United States
P30 CA006516/CA/NCI NIH HHS/United States
U01 HG007942/HG/NHGRI NIH HHS/United States