Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation

Ane Olazagoitia-Garmendia; Henar Rojas-Márquez; Maria Del Mar Romero; Pamela Ruiz; Aloña Agirre-Lizaso; Yantao Chen; Maria Jesus Perugorria; Laura Herrero; Dolors Serra; Cheng Luo; Luis Bujanda; Chuan He; Ainara Castellanos-Rubio

doi:10.1136/gutjnl-2023-330459

Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation

Gut. 2024 Aug 8;73(9):1590-1592. doi: 10.1136/gutjnl-2023-330459.

Authors

Ane Olazagoitia-Garmendia^{1

2}, Henar Rojas-Márquez^{2

3}, Maria Del Mar Romero^{4

5

6}, Pamela Ruiz^{7

8}, Aloña Agirre-Lizaso⁹, Yantao Chen¹⁰, Maria Jesus Perugorria^{9

11

12}, Laura Herrero^{4

5

6}, Dolors Serra^{4

5

6}, Cheng Luo^{10

13}, Luis Bujanda^{9

11

12}, Chuan He^{14

15}, Ainara Castellanos-Rubio^{16

3

17

18}

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of the Basque Country, UPV/EHU, Leioa, Spain.
² Biobizkaia Health Research Institute, Barakaldo, Spain.
³ Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain.
⁴ Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.
⁵ Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
⁶ Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
⁷ Research Centre for Experimental Marine Biology and Biotechnology (PiE-UPV/EHU), University of the Basque Country, UPV/EHU, Plentzia, Spain.
⁸ BCTA Research Group, Department of Zoology and Animal Cell Biology, University of the Basque Country, UPV-EHU, Leioa, Spain.
⁹ Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, Donostia-san Sebastian, Spain.
¹⁰ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Beijing, Beijing, China.
¹¹ Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, Spain.
¹² Centro de Investigación Biomédica en Red enfermedades hepaticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
¹³ Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
¹⁴ Department of Chemistry, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.
¹⁵ Howard Hughes Medical Institute, Chicago, Illinois, USA.
¹⁶ Biobizkaia Health Research Institute, Barakaldo, Spain [email protected].
¹⁷ Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
¹⁸ IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

No abstract available

Keywords: CELIAC DISEASE; INFLAMMATION; METHYLATION.

Publication types

Letter

MeSH terms

Animals
Caffeic Acids / pharmacology
Caffeic Acids / therapeutic use
Glutens* / adverse effects
Humans
Lactates / pharmacology
Lactates / therapeutic use
Mice
RNA-Binding Proteins / metabolism

Substances

Glutens
RNA-Binding Proteins
Caffeic Acids
Lactates
salvianolic acid A

Grants and funding

RM1 HG008935/HG/NHGRI NIH HHS/United States