How degrading! Trapped translation factors get trashed

Pierce W Ford; Eric J Bennett

doi:10.1016/j.celrep.2023.113278

How degrading! Trapped translation factors get trashed

Cell Rep. 2023 Nov 28;42(11):113278. doi: 10.1016/j.celrep.2023.113278. Epub 2023 Oct 31.

Authors

Pierce W Ford¹, Eric J Bennett²

Affiliations

¹ School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093.
² School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093. Electronic address: [email protected].

PMID: 37910507
DOI: 10.1016/j.celrep.2023.113278

Abstract

Using small molecules that trap translation factors within translating ribosomes, Gurzeler et al.¹ and Oltion et al.² identify a new branch of the ribosome-associated quality-control (RQC) pathway. This mode of translation regulation expands the number of mechanistically distinct RQC pathways.

Publication types

Comment

MeSH terms

Protein Biosynthesis
Protein Processing, Post-Translational
Ribosomes / metabolism
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins* / metabolism

Substances

Saccharomyces cerevisiae Proteins