Exposure to low levels of hydrogen sulphide and its impact on chronic obstructive pulmonary disease and lung function in the geothermal area of Mt. Amiata in Italy: The cross-sectional InVETTA study

PLoS One. 2023 Nov 1;18(11):e0293619. doi: 10.1371/journal.pone.0293619. eCollection 2023.

Abstract

Background: The geothermal power plants for electricity production currently active in Italy are all located in Mt. Amiata area in the Tuscany region. A cross-sectional survey was conducted in the framework of the regional project "InVETTA-Biomonitoring Survey and Epidemiological Evaluations for the Protection of Health in the Amiata Territories", using objective measures of lung function to investigate the role of hydrogen sulphide (H2S) in affecting the respiratory health of the population living in this area.

Methods: 2018 adults aged 18-70 were enrolled during 2017-2019. Home and workplace addresses of participants were geocoded. Dispersion modelling was used to evaluate the spatial variability of exposure to H2S from the geothermal power plants' emissions. We estimated average long-term historical exposure to H2S and more recent exposure indicators. Chronic Obstructive Pulmonary Disease (COPD) was defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Multivariable logistic regressions were performed to investigate associations between outcome and exposure.

Results: Our findings did not showed any evidence of an association between increasing H2S exposure and lung function impairments. Some risk reductions were observed: a -32.8% (p = 0.003) for FEV1<80% and a -51.7% (p = 0.001) risk decrease for FVC<80% were associated with interquartile increase (13.8 μg/m3) of H2S levels.

Conclusion: Our study provides no evidence that chronic exposure to low levels of H2S is associated with decrements in pulmonary function, suggesting that ambient H2S exposure may benefit lung function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Humans
  • Hydrogen Sulfide* / analysis
  • Italy / epidemiology
  • Lung / chemistry
  • Pulmonary Disease, Chronic Obstructive* / epidemiology

Substances

  • Hydrogen Sulfide

Grants and funding

This work was supported by regional funding provided by Tuscany Region – Direzione Generale Politiche Ambientali, Energia e Cambiamenti Climatici (Resolution N. 973 on November 10, 2014)(Grant recipient: Dr. Fabio Voller). The funding source had no role in the study design, data collection, analysis and interpretation of data, the writing of the report, and the decision to submit the article for publication.