Radiotherapy for Non-Hodgkin's lymphoma with cardiac infiltration: A case report

Weifeng Wang; Zhuo Zhang; Xiaocong Deng; Anqi Gu; Xianzhao Chen; Yizheng Cai; Yuting Zhao

doi:10.3389/fonc.2023.1234831

Radiotherapy for Non-Hodgkin's lymphoma with cardiac infiltration: A case report

Front Oncol. 2023 Oct 17:13:1234831. doi: 10.3389/fonc.2023.1234831. eCollection 2023.

Authors

Weifeng Wang¹, Zhuo Zhang¹, Xiaocong Deng¹, Anqi Gu¹, Xianzhao Chen¹, Yizheng Cai¹, Yuting Zhao¹

Affiliation

¹ Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, China.

Abstract

Background: Non-Hodgkin's lymphoma (NHL) with cardiac infiltration has a poor prognosis. The median OS of patients failing to respond to chemotherapy has been reported to be 1 month vs. 18 months in patients responding to chemotherapy.

Case presentation: Herein, we reported a case of a 57-year-old male confirmed with diffuse large B-cell lymphoma who received radiation therapy of 150-cGy daily, administered in 30 fractions to the volume of cardiac infiltration, resulting in complete relief. Chemotherapy had no curative effect. The patient was subsequently enrolled in a clinical trial and received oral administration of zanubrutinib 80mg twice daily, after which he achieved complete remission. The progression-free survival was from diagnosis (January 7, 2020) to the follow-up (September 20, 2022), amounting to 32 months.

Conclusion: Proper irradiation dose and timing of treatment can relieve NHL symptoms.

Keywords: Non-Hodgkin’s lymphoma; cardiac infiltration; case report; radiotherapy; zanubrutinib.

Publication types

Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.