Higher MDMX expression was associated with hypomethylating agent resistance and inferior survival in MDS patients, inferring it a potential therapeutic target
Leukemia
.
2023 Dec;37(12):2507-2511.
doi: 10.1038/s41375-023-02044-2.
Epub 2023 Nov 2.
Authors
Yu-Hung Wang
1
2
,
Chien-Chin Lin
3
4
,
Kristian Gurashi
2
,
Bettina Wingelhofer
5
,
Fabio M R Amaral
5
,
Chi-Yuan Yao
1
6
,
Hsin Ting Hsieh
7
,
Ming Chih Liu
7
,
Hsin-An Hou
1
,
Wen-Chien Chou
1
6
,
Kiran Batta
2
,
Daniel H Wiseman
2
,
Hwei-Fang Tien
8
9
Affiliations
1
Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
2
Epigenetics Haematopoiesis Laboratory, Division of Cancer Sciences, The University of Manchester, Manchester, UK.
3
Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
[email protected]
.
4
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
[email protected]
.
5
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, Manchester, UK.
6
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
7
Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
8
Division of Hematology, National Taiwan University Hospital, Taipei, Taiwan.
[email protected]
.
9
Department of Internal Medicine, Fra-Eastern Memorial Hospital, New Taipei City, Taiwan.
[email protected]
.
PMID:
37919605
DOI:
10.1038/s41375-023-02044-2
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
Azacitidine / pharmacology
Azacitidine / therapeutic use
Humans
Myelodysplastic Syndromes* / drug therapy
Myelodysplastic Syndromes* / genetics
Prognosis
Substances
Azacitidine
Grants and funding
RCCASF-NOV22/100001/CRUK_/Cancer Research UK/United Kingdom