Cefazolin and Carbapenem Combination to Treat Persistent Methicillin-sensitive Staphylococcus aureus Bacteremia in Preterm Infants

Pediatr Infect Dis J. 2024 Feb 1;43(2):145-148. doi: 10.1097/INF.0000000000004155. Epub 2023 Oct 27.

Abstract

Encouraged by bacteremia clearance using antistaphylococcal beta-lactams plus carbapenem combination in adults with refractory methicillin-sensitive Staphylococcus aureus infection, we present our experience with 2 preterm infants and review 1 previously published case. Noted successful bacteremia clearance in all 3 must be weighed against possible adverse effects associated with carbapenem use.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents* / administration & dosage
  • Anti-Bacterial Agents* / adverse effects
  • Anti-Bacterial Agents* / therapeutic use
  • Bacteremia* / drug therapy
  • Bacteremia* / microbiology
  • Carbapenems* / therapeutic use
  • Cefazolin* / therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Staphylococcal Infections* / drug therapy
  • Staphylococcal Infections* / microbiology
  • Staphylococcus aureus* / drug effects
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Cefazolin