The authors report on 4 observations they have made in cases of full-blown sickle-cell disease who became pregnant, to demonstrate that: fertility is normal in women with sickle-cell disease, it is important to screen systematically for haemoglobinopathies in populations at risk, that the condition is relatively rare, and very high-risk pregnancies do not happen very often in cases of full-blown sickle-cell disease. They recite the difficulties in providing for an efficient form of contraception with little danger in these patients.