Dissecting the biophysics and biology of intrinsically disordered proteins

Trends Biochem Sci. 2024 Feb;49(2):101-104. doi: 10.1016/j.tibs.2023.10.002. Epub 2023 Nov 8.

Abstract

Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.

Keywords: cancer; condensates; phase separation; single-molecule microscopy.

MeSH terms

  • Biology
  • Biophysics
  • Humans
  • Intrinsically Disordered Proteins* / metabolism

Substances

  • Intrinsically Disordered Proteins