Study of Cytotoxic and Antibacterial Activity of Ag- and Mg-Dual-Doped ZnO Nanoparticles

Aytan Azizi; Mohammad Ghasemirad; Bardia Mortezagholi; Emad Movahed; Seyed Sasan Aryanezhad; Ali Makiya; Hoda Ghodrati; Kamyar Nasiri

doi:10.1002/open.202300093

Study of Cytotoxic and Antibacterial Activity of Ag- and Mg-Dual-Doped ZnO Nanoparticles

ChemistryOpen. 2024 Mar;13(3):e202300093. doi: 10.1002/open.202300093. Epub 2023 Nov 13.

Authors

Aytan Azizi¹, Mohammad Ghasemirad², Bardia Mortezagholi³, Emad Movahed³, Seyed Sasan Aryanezhad⁴, Ali Makiya⁵, Hoda Ghodrati⁶, Kamyar Nasiri⁷

Affiliations

¹ Department of Endodontics Dental School, Qazvin university of medical sciences, shahid bahounar boulevard, P.O. Box: 3419759811, Qazvin, Iran.
² Department of Periodontics Faculty of Dentistry, Rafsanjan University of Medical Sciences, Khalije Fars Blvd., Pasdaran street, P.O. Box: 1946853314, Rafsanjan, Iran.
³ Dental Research Center Faculty of Dentistry, Islamic Azad University of Medical Sciences, Shariati St, P.O. Box 19395-1495, Tehran, Iran.
⁴ Oral and Maxillofacial Radiology, Private Practice, Daroost street, P.O. Box 1944614581, Tehran, Iran.
⁵ Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Science, Mashhad, Iran.
⁶ Department of Prosthodontics, Shahid Beheshti University of Medical Sciences, Daneshjoo Blvd, Velenjak, St., P.O. Box 1983969411, Tehran, Iran.
⁷ Department of dentistry, Islamic Azad University of Medical Sciences, P.O. Box 19585-466, Tehran, Iran.

Abstract

A non-laborious process for the fabrication of silver and magnesium dual doped zinc oxide nanoparticles (Ag/Mg-ZnO NP) is described. The wurtzite ZnO nano-structures and the dual doped NP were analyzed by PXRD. SEM data showed the hexagonal morphology of our product, while the gathered anti-bacterial outcomes towards Streptococcus mutans bacteria through micro-dilution technic affirmed the enhanced performance of doped NP compared to the native ones. Furthermore, we gauged the toxic impacts of synthesized pure and Ag/Mg-ZnO NP against a breast cancer (MDA-MB-231) cell line through an MTT trial, which highlighted the superiority of the doped when compared to the native nanoparticles. In light of these comparisons, the applicability of Ag/Mg-ZnO NP in dental and medical science is proposed.

Keywords: Ag/Mg−ZnO; Scanning Electron Microscopy; Streptococcus mutans; human breast cancer; well-diffusion.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Nanoparticles*
Silver / chemistry
Silver / pharmacology
Zinc Oxide* / chemistry
Zinc Oxide* / pharmacology

Substances

Zinc Oxide
Anti-Bacterial Agents
Silver
Antineoplastic Agents