Feeling at home: Identifying a human thymic epithelial progenitor cell niche

Dante V Acenas 2nd; Jarrod A Dudakov

doi:10.1016/j.devcel.2023.10.015

Feeling at home: Identifying a human thymic epithelial progenitor cell niche

Dev Cell. 2023 Nov 20;58(22):2411-2412. doi: 10.1016/j.devcel.2023.10.015.

Authors

Dante V Acenas 2nd¹, Jarrod A Dudakov²

Affiliations

¹ Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA.
² Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA. Electronic address: [email protected].

PMID: 37989079
DOI: 10.1016/j.devcel.2023.10.015

Abstract

T cell development relies on a supportive epithelial microenvironment. Embryonic and postnatal epithelial progenitors have been identified in mice, but not humans. In this issue of Developmental Cell, Raggazzini et al. use scRNAseq, spatial sequencing, and clonogenic assays to identify a putative bipotent TEPC in pediatric human thymic tissue.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation
Child
Epithelial Cells
Humans
Mice
Stem Cell Niche
Stem Cells*
Thymus Gland*