Validation, visibility, vagueness and variation: A qualitative assessment of existing veterinary guidelines for antimicrobial use in cattle and sheep in the UK

PLoS One. 2023 Nov 30;18(11):e0294733. doi: 10.1371/journal.pone.0294733. eCollection 2023.

Abstract

Antimicrobials are essential in veterinary medicine to treat and control bacterial disease in animals. Their prudent use in food-producing animals has been encouraged to reduce the development and spread of antimicrobial resistance. National and international guidelines for responsible antimicrobial use have been developed as tools to guide and rationalise antimicrobial prescribing decisions by veterinarians and usage decisions by farmers. Yet, there is little understanding of whether these existing guidelines are fit for purpose. Accordingly, this study rigorously assessed 128 veterinary guidelines for antimicrobial use in ruminants in the UK, following established qualitative methodologies. Findings revealed four pertinent themes: validation of the veterinarian as the prescriber, visibility of responsible use realities, vagueness in interpretation and variation in directing behaviour. These themes encompassed the roles and responsibilities of the veterinarian and the realities of prescribing scenarios, alongside concerns relating to the specificity within and variation between guidelines. Resultant recommendations to inform and support the future development of guidelines include establishing species-specific and disease-specific guidelines, expanding guidelines to include disease prevention measures, including definitions to resolve vagueness and promoting congruence in interpretation, encouraging the development of practice-level guidelines to endorse collaboration and ownership, and fostering active working between stakeholders to align priorities and messaging.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents* / therapeutic use
  • Bacterial Infections* / drug therapy
  • Cattle
  • Farmers
  • Humans
  • Sheep
  • United Kingdom
  • Veterinarians*

Substances

  • Anti-Infective Agents
  • Anti-Bacterial Agents

Grants and funding

Funding was provided to AMB, GMR and KKR by the Welsh Government through the Rural Development Programme (https://businesswales.gov.wales/walesruralnetwork/wrn-support-unit/rural-development-programme-fundingwebsite). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.