Advancements in engineered exosomes for wound repair: current research and future perspectives

Hailian Ye; Feng Wang; Guangchao Xu; Feihong Shu; Kunwu Fan; Dali Wang

doi:10.3389/fbioe.2023.1301362

Advancements in engineered exosomes for wound repair: current research and future perspectives

Front Bioeng Biotechnol. 2023 Nov 14:11:1301362. doi: 10.3389/fbioe.2023.1301362. eCollection 2023.

Authors

Hailian Ye^{1

2}, Feng Wang³, Guangchao Xu^{1

2}, Feihong Shu^{1

2}, Kunwu Fan³, Dali Wang^{1

2}

Affiliations

¹ Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
² The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, Guizhou, China.
³ Department of Burn and Plastic Surgery, Department of Wound Repair, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.

Abstract

Wound healing is a complex and prolonged process that remains a significant challenge in clinical practice. Exosomes, a type of nanoscale extracellular vesicles naturally secreted by cells, are endowed with numerous advantageous attributes, including superior biocompatibility, minimal toxicity, and non-specific immunogenicity. These properties render them an exceptionally promising candidate for bioengineering applications. Recent advances have illustrated the potential of exosome therapy in promoting tissue repair. To further augment their therapeutic efficacy, the concept of engineered exosomes has been proposed. These are designed and functionally modifiable exosomes that have been tailored on the attributes of natural exosomes. This comprehensive review delineates various strategies for exosome engineering, placing specific emphasis on studies exploring the application of engineered exosomes for precision therapy in wound healing. Furthermore, this review sheds light on strategies for integrating exosomes with biomaterials to enhance delivery effectiveness. The insights presented herein provide novel perspectives and lay a robust foundation for forthcoming research in the realm of cutaneous wound repair therapies.

Keywords: biomaterials; engineered exosomes; exosomes; precision therapye; wound repair.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (81871570 and 82072195), the Science and Technology Plan Project of Guizhou Province [(2020)4Y148], and the Chinese Ministry of Education (2020-39). The Key Clinical Specialty-Burn Surgery of Guandong Province, China (NO. 2000004); 1038083_KF of Tsinghua University Shenzhen Research Institute—Research on Severe Burn Skin Repair and Regeneration, China (NO. 2020N358); Guangdong Medical Science and Technology Research Foundation, China (NO. A2021077). Sanming project-Professor Lv Guozhong, Affiliated Hospital of Jiangnan University, Burn and Plastic Surgery Team, China (NO.3000034); 2000022_National Key Specialty for Burn Surgery, China ([2023] No. 25).