Abstract
The synthesis of new 3,5-diamino-1,2,6-thiadiazine 1,1-dioxide derivatives is described and their structures discussed on the basis of 1H and 13C-N.M.R. data. The antiparasitic activity of these and related compounds was evaluated. The bacterial mutagenicity of the parent compound (I) was studied.
MeSH terms
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Amebicides / chemical synthesis
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Animals
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Antifungal Agents / chemical synthesis
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Antimalarials / chemical synthesis
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Antitrichomonal Agents / chemical synthesis
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Chemical Phenomena
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Chemistry
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Mutagens
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Parasites / drug effects*
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Thiadiazines / chemical synthesis*
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Thiadiazines / pharmacology
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Thiadiazines / toxicity
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Thiazines / chemical synthesis*
Substances
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Amebicides
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Antifungal Agents
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Antimalarials
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Antitrichomonal Agents
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Mutagens
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Thiadiazines
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Thiazines