Photocatalytic N-Alkylation of N H-Diaryl Sulfondiimines via Anti-Markovnikov Hydroamination with Styrenes

Org Lett. 2023 Dec 15;25(49):8861-8865. doi: 10.1021/acs.orglett.3c03608. Epub 2023 Dec 7.

Abstract

Sulfondiimines, which are isoelectronic with sulfones and sulfoximines, represent a neglected yet intriguing pharmacophore in the discovery program. Herein, we present a facile and mild photocatalytic anti-Markovnikov hydroamination of styrenes for the construction of N-alkylated sulfondiimines with primary, secondary, and tertiary alkyl substituents. A sulfondiimine-derived analogue of the marketed drug Vioxx was synthesized using this method as the key step.