Objective: To analyze the disease burden and change trend of lung cancer attributable to chromium in Chinese population from 1990 to 2019, and to provide reference for the formulation of health policies and strategies of disease prevention and control. Methods: In October 2022, using the data and findings of the burden of disease, injury and risk factor published in the Global Burden of Disease Study 2019 (GBD 2019), the burden of lung cancer and its changes caused by occupational hexavalent chromium exposure in Chinese population from 1990 to 2019 were analyzed according to year and gender. The average age structure of the world population was used as the standard population to calculate standardized indicators, and then compared with the global population. Results: The incidence number, death number, disability adjusted life years (DALY) of lung cancer attributable to chromium in Chinese population of 2019 were 833 cases, 790 cases and 22118 person years, respectively. Compared with 1990 (257 cases, 277 cases, 8631 person years), the increase was 224.1%, 185.2%, 156.3%, higher than the global level (101.0%, 134.2%, 117.2%). The standardized morbidity, mortality and DALY rates of lung cancer attributable to chromium in Chinese population of 2019 were 0.059/100000, 0.056/100000 and 1.555/100000, which respectively increased by 169.7%, 137.4%, 113.3% in comparison with that of 1990 (0.022/100000, 0.023/100000 and 0.729/100000). The average annual percent changes were 18.8%, 15.1% and 13.5%, which were higher than the global level (5.7%, 8.4% and 7.0%). In 2019, the DALY caused by chromium-related lung cancer in the Chinese population accounted for 0.0058% (22118/382205568) of the all-cause disease burden in the Chinese population, and 51.8% (22118/42718) of the global population. In 2019, the disease burden of lung cancer attributable to chromium was higher in males than in females, the number of incidence, death and DALY were 576 cases (69.1%), 525 cases (66.5%) and 14717 person years (66.5%), respectively. Conclusion: In 2019, the proportion of disease burden caused by lung cancer attributable to chromium in the Chinese population is low, but it accounts for a high proportion of the global population burden of lung cancer attributable to chromium, and the standardized incidence, mortality and DALY rates show an increasing trend year by year from 1990 to 2019.
目的： 分析1990至2019年中国人群铬相关肺癌的疾病负担及其变化趋势，为制定卫生政策和疾病防控策略提供参考依据。 方法： 于2022年10月，利用全球疾病负担研究2019（Global Burden of Disease Study 2019，GBD 2019）公开的疾病、伤害和危险因素负担情况的数据和研究结果，按照年份、性别等，分析1990至2019年中国人群职业性六价铬暴露导致的肺癌疾病负担及其变化情况。采用世界人口的平均年龄结构作为标准人口计算标化指标，进而与全球人群进行比较。 结果： 2019年中国人群铬相关肺癌的发病数、死亡数及伤残调整寿命年数（disability adjusted life years，DALY）分别为833例、790例、22 118人年，较1990年（257例、277例、8 631人年）分别增长224.1%、185.2%、156.3%，增幅均高于全球相应水平（101.0%、134.2%、117.2%）；而2019年的标化发病率、死亡率及DALY率分别为0.059/10万、0.056/10万、1.555/10万，较1990年（0.022/10万、0.023/10万、0.729/10万）分别上升169.7%、137.4%、113.3%，平均年度变化百分比分别为18.8%、15.1%、13.5%，均高于全球水平（5.7%、8.4%、7.0%）。2019年中国人群因铬相关肺癌造成的DALY占中国人群所有原因疾病负担的0.005 8%（22 118/382 205 568），占全球人群铬相关肺癌DALY的51.8%（22 118/42 718）。2019年中国人群中男性铬相关肺癌发病数、死亡数及DALY数分别为576例（69.1%）、525例（66.5%）、14 717人年（66.5%），其疾病负担高于女性。 结论： 2019年中国人群铬相关肺癌导致的疾病负担占全因疾病负担的比例低，但占全球人群铬相关肺癌疾病负担的比例高，且1990至2019年标化发病率、死亡率、DALY率呈逐年上升趋势。.
Keywords: Burden of disease; Chromium; Disability adjusted life years, DALY; Hexavalent chromium; Lung cancer.